Thanksgiving is set to feature a division matchup between the San Francisco 49ers and Seattle Seahawks. Both teams will be missing key starters on offense as they face off in a highly anticipated game.

The 49ers will be without starting right guard Spencer Burford, who is dealing with a knee injury. While his absence may not be significant, Jon Feliciano is poised to step in as a solid replacement. Seattle, on the other hand, will be missing running back Kenneth Walker III, who sustained an oblique injury in their previous game. Rookie Zach Charbonnet will look to fill the void.

The absence of Walker might make it easier for the 49ers to focus on the dynamic Seahawks' wide receiver duo of D.K. Metcalf and Tyler Lockett, who have troubled the 49ers in the past. Additionally, Seahawks quarterback Geno Smith may not be at full health after suffering an elbow injury.

Both teams will be missing key players, but the Thanksgiving matchup is still expected to be exciting. The 49ers, favored by more than a touchdown, will look to overcome injuries and maintain their lead in the NFC West standings.

Sources:

- ESPN: "49ers-Seahawks injury report: Seattle is down 3 starters"

- NBC Sports: "49ers vs. Seahawks odds, line: 2023 Thanksgiving Day NFL picks, predictions from expert on 18-7 run"

- CBS Sports: "49ers vs. Seahawks odds, line, spread: 2023 Thanksgiving Day NFL picks, predictions from dialed-in expert"