The Buffalo Bills will be facing a tough challenge on defense as they take on the Philadelphia Eagles and their strong passing attack. After dealing with uncertainties in their secondary, the Bills head into the game with their full group of starting cornerbacks and safeties. Nickel cornerback Taron Johnson has cleared concussion protocol and safety Micah Hyde is also good to go despite dealing with a stinger. The duo, along with cornerbacks Rasul Douglas, Christian Benford, and safety Jordan Poyer, will have their hands full with the likes of DeVonta Smith and the returning Quez Watkins. However, the focal point of the Eagles passing attack is A.J. Brown, who has had success against the Bills in the past when he played for the Titans. The Bills will need to decide how to defend the 6-foot-1, 227-pound Brown, whether to have Douglas travel with him or have the nickel corner Johnson cover him when he moves to the slot. It will be a test of the Bills' secondary to contain the explosive Eagles passing attack.

On the offensive side, the Bills will be looking to build on their success from last week when new interim offensive coordinator Joe Brady took over. They will need to prove that their improved performance was not just a one-week boost but something sustainable. One key factor in their success was sticking with the rushing game and utilizing James Cook. With the threat of the run, it opened up opportunities for the Bills' passing attack led by quarterback Josh Allen. Allen looked more comfortable and decisive, resulting in more downfield shots. The Bills will aim to replicate this offensive success against the high-powered Eagles defense.

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